Insulina en pastillas ¿una realidad cercana?

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A casi todo el mundo le gustan las cosas dulces, pero pueden llegar a ser un gran problema: el abuso de ellas conduce a la diabetes. Hay casi 350 millones de personas afectadas por esta enfermedad, la cual podría llegar a los 500 millones para 2030. Uno de los inconvenientes de la diabetes es el tener que inyectarse insulina de manera periódica, la cual ayuda a regular los niveles de azúcar en la sangre. Sin embargo, para muchos resultaría más cómodo tomar una pastilla, pero estamos ante una proteína que se encarga de destruir los ácidos del estómago y demasiado grande para que el intestino delgado la absorba.

Por su parte, el Instituto Nacional de Educación Farmacéutica en India ya dio con una solución en 2012, pero dichos comprimidos resultaban ser demasiado caros. Ahora ha llegado una nueva propuesta que luce bastante prometedora. La insulina se protege mediante grasas para que llegue intacta al estómago, luego se mezcla con ácido cólico para permitir que la molécula de gran tamaño se dirija al torrente sanguíneo. En las pruebas que se han realizado hasta ahora -las cuales han sido en animales- variaba la cantidad de compuesto que llegaba a la sangre, pero funcionaba de forma correcta. El efecto de una inyección dura entre seis y ocho horas, mientras que estas pastillas funcionan durante más de dieciocho horas.

El problema aquí es que las pruebas en animales no siempre dan el mismo resultado en personas y aún así se necesitará de mucho trabajo adicional. Hasta ahora no se sabe si esto finalmente se llevará a cabo ya que los investigadores no tienen en claro si recibirán el financiamiento necesario para concretar la investigación. Esperemos que lo consigan pues harán mucho más llevadero el tratamiento de 350 millones de personas.

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Amante de la tecnología, estudiante de ciencias de la comunicación. Siempre abierto a probar nuevas tecnologías.

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